Comparison of rabbit rib defect regeneration with and without graft

Feng-Zhen Liu,Yu-Jue Zhang,Zhao Yong Lv,Ke-Yi Li,Bin Zhang,Xiu-Mei Wang,Xiao-Dan Sun,Fu-Zhai Cui,Da-Wei Wang

doi:10.1007/s10856-016-5807-1

Abstract

Rib segment, as one of the most widely used autologous boneresources for bone repair, is commonly isolated with an empty left in the defect. Although defective rib repair is thought to be unnecessary traditionally, it’s of vital importance actually to promote rib regeneration for patients with better postoperative recovery and higher life quality. Comparative investigations on rabbit rib bone regeneration with and without graft were reported in this article. A segmental defect was performed on the 8th rib of 4-month-old male New Zealand rabbits. The mineralized collagen bone graft (MC) was implanted into the defect and evaluated for up to 12 weeks. The rib bone repair was investigated by using X-ray at 4, 8 and 12 weeks and histological examinations at 12 weeks after surgery, which showed a higher bone remodeling activity in the groups with MC implantation in comparison with blank control group, especially at the early stage of remodeling.

Highlights

Rib defects are quite common in clinic, which can occur as a result of trauma, thoracotomy, and autologous bone harvest [1–5]
The purpose of this work was to investigate the effect of mineralized collagen bone graft (MC) bone materials on promoting the rabbit rib defect
X-ray radiographs showed the 3 cm defects were covered with homogeneous opacity and bone union in the MC group, as shown in Fig. 2 (Group B)

Summary

Introduction

Rib defects are quite common in clinic, which can occur as a result of trauma, thoracotomy, and autologous bone harvest [1–5]. Little attention was paid to the rib defect reconstruction as it was always thought to have little impact on patient’s respiratory function. The defective ribs are not treated after being harvested, which will lead to a lot of adverse influences, such as chest wall deformities, cardiopulmonary insufficiency problems, and so on so forth [9]. With the development of improved surgical techniques and the increase on patients’ esthetic concerns, rib defect repair has gradually gained more and more attentions. It is valuable to investigate the repair and regeneration of rib defects by means of tissue-engineered bone grafts

Objectives

Results

Conclusion