Abstract
A novel, sensitive, and rapid analytical method for analyzing valifenalate residue in grape, vegetables (tomato, lettuce, eggplant, potato), and soil was established and validated using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method by ultrahigh performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). The determination of the analyte was achieved within 4 min for per injection using electrospray ionization (ESI) operated in positive ion mode, and the retention time was 1.92 min. The developed method exhibited good linearity (R2 ≥ 0.9941) and the limit of quantitation (LOQ) was 0.5 μg/kg for analyte in selected matrices. The mean recoveries in six matrices ranged from 74.5 to 106.6% with intra-day relative standard deviation (RSD) of 0.7–12.3% and inter-day RSD of 3.2–12.2% at four spiking levels (0.5, 10, 100, 500 μg/kg) in recovery assays. The proposed method was applied to explore the dissipation rates of valifenalate in grapes and soil under field conditions, and the half-lives of analyte in grape and soil were 15.5 ± 1.4 and 3.8 ± 0.1 days, respectively. The study indicated that the method was effective and reliable for detection of valifenalate residues and the dissipation data can provide reference towards safety application for the analyte.
Published Version
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