Abstract
A phase-sensitive weak measurement biosensor was proposed for the detection of carcinoembryonic antigen (CEA), one common category of tumor markers. The total internal reflection (TIR) at the interface of the prism without precious metal coating was exploited to introduce the phase delay between horizontal and vertical polarizations, which can be determined through the central wavelength shift of output spectra for the sensing of the refractive index of the sample. In the weak measurement analysis, the specific binding reaction of tumor markers with a refractive index change on the surface of the prism can be monitored in real time through the central wavelength shift. With the specific absorption measurement, the feasibility of this weak measurement-based biosensor was experimentally demonstrated. We provide a low cost and convenient approach for tumor marker detection.
Highlights
Tumor markers are always found in blood, urine, or body tissues, and they present a higher level in patients with one or more types of cancer compared with normal patients [1]
In the weak measurement system, the central wavelength shifts of the the output spectra are quantitatively correlated with the phase difference
The measuring output spectra are quantitatively correlated with the phase difference
Summary
Tumor markers are always found in blood, urine, or body tissues, and they present a higher level in patients with one or more types of cancer compared with normal patients [1]. The ultra-sensitive detection of tumor markers contributes to the early diagnosis and clinical treatment of tumors [2]. Greater attention has been paid to the detection of tumor markers for the purpose of early diagnosis and treatment, which is of profound significance to cancer patients. For this reason, technology that can operate in real time at high precision for the detection of tumor markers would be useful. Current methods for the detection of tumor markers, including electrochemistry [3,4,5], fluorescence [6,7,8], chemiluminescence [9,10], and graphene-based biosensors [11,12,13], provide sensitive and specific techniques.
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