Abstract
The microbeam synchrotron X‐ray fluorescence (MSXRF) technique is powerful tool for determining elemental composition and spatial distribution of elements within materials on the microscopic level. Therefore, application of this technique seems to be helpful for investigation of the role of trace elements in neurodegenerative processes. As a preliminary study the MSXRF technique was applied for elemental microanalysis in cryo‐sections of substantia nigra tissue for cases of Parkinson's disease (PD) and the control. Two‐dimensional maps of elemental distribution showed significant topographic and quantitative differences between the pathological and control tissues. Quite interesting is significant increased accumulation of Ca, Cu, Fe, Fe, and Zn that was observed in PD neuron perikaryal parts.
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