Abstract
Plantago laceolata considered as an ancient herb promising plant. In this work, the target of the study was designed to estimate total flavonoids, anti-oxidant and chemical composition of Plantago laceolata aqueous extract in vitro. Total flavonoids content was;evaluated in the extract, and it was 317.0000 ± 9.64365mg /ml. also, anti-oxidant activity of Plantago laceolata aqueous extract in vitro was assessed in vitro via evaluation of reductive ability. At all concentrations of plant extract tested (0.02, 0.04, 0.08, 0.16, 0.32 and 0.64 mg/ml) in reductive ability; the absorbance was increase significantly in all dependent concentration manner. also, the aqueous plant extract was increase significantly The results of chemical composition of plant showed contain Tannins, polysaccharide, Alkaloids,Flavonoids and Polyphenolic Compounds . Also plant extracts counteract the damage caused by methotrexate drug through the reduction in liver enzymes GOT, GPT and ALP in all groups of mice the results of interactions indicated the ability of plant to modulating harmful effects of the drug in liver and its enzymes when administration to albino mice male in 200mg/kg.
Highlights
Among the medicinal herbs species of therapeutic interest is included P. lanceolata. which is a type of the genus in the family named Plantaginaceae originated from Europe, commonly spread throughout the world
Total flavonoid Total flavonoids content were spectrophoto-chemically determined in aqueous extract of P. lanceolata as rutin equivalent
Active chemical constituent in plant Determination active constituents of Plantago lanceolata aqueous extract showed that chemical composition of plant contain (Tannin, polysaccharide, alkaloid,flavonoid, polyphenol compound) as in table 3
Summary
Among the medicinal herbs species of therapeutic interest is included P. lanceolata. which is a type of the genus in the family named Plantaginaceae originated from Europe, commonly spread throughout the world. Among the medicinal herbs species of therapeutic interest is included P. lanceolata. Plantago lanceolata, was grows to a tall about 40–60 cm and yields a rosette of leaves, sometimes up to 50 cm, in tall [2]. The complex chemical composition of P. lanceolata L. species is represented by a series of categories of substances, among which the main components are: iridoid glycosides, polysaccharides (plantaglucide, glucomannan), flavonoids and flavone glycosides, phenolic carboxylic acids, alkaloids (indicain, plantagonin), terpenoids As a result of the presence of active metabolites, Plantago major L. is used in cosmetic and pharmaceutical industries. Anti-diarrhea, anti-cancer and antibacterial activates have been described in different sources as some of the health benefits of this plant [4]. Which concluded that plant had beneficial effect on health Anti-diarrhea, anti-cancer and antibacterial activates have been described in different sources as some of the health benefits of this plant [4]. which concluded that plant had beneficial effect on health
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