Determination of the Role of T-Helper 17 and 22 vs T-reg Cells in Patients with Molluscum Contagiosum

Abstract

Molluscum contagiosum is skin disease and well known by dermatologists, the causative agent is a pox virus. Infection, usually self-limited within few months in individuals with a normal health and immune system. From 205 case females recorded 95(46.3%) and 110(53.7%) males. The results showed that there were a highly significant increment in concentration of IL-17A (132.66 ± 24.7pg/ml) compared with control group which was (42.59±13.4pg/ml). Results also showed that there is highly significant increment in concentrations of IL-23P19 (112.33 ±17pg/ml) compared with control group which was (21.11±9.6pg/ml). Also documented data declared a highly significant increment in concentrations of IL-22 (77.11±8.8pg/ml) in comparison to control group which was (18.11±12pg/ml). The relative expression of the gene FoxP3 gene showed increment in patients group (17.723 ± 1.227) compared with control group which was (2.133±1.234), results of NFAT gene showed increment in patients group (13.676±2.223) compared with control group which was (2.743±1.133) and result of AP1gene showed increment in patients group (3.7883±1.234) compared with control group which was (1.8766±0.889). These findings indicate the potent immune response against the virus infection which belongs to Th-17 and 22 and the controlling mechanisms through the regulatory T-cells which maintain the response in the normal levels.