Abstract
The acid–base equilibrium constants of the β-blockers atenolol, oxprenolol, timolol and labetalol were determined by automated potentiometric titrations. The p K a values were obtained in water-rich or water–methanol medium (20% MeOH) to obviate the solubility problems associated with the compounds. The initial estimates of p K a values were obtained from Gran's method and then, were refined by the NYTIT and ZETA versions of the LETAGROP computer program. The resultant values were 9.4 ( I=0.1 M KCl, 20% methanol) for atenolol, 9.6 ( I=0.1 M KCl) for oxprenolol, 9.4 ( I=0.1 M KCl, 20% methanol) for timolol and 7.4 and 9.4 ( I=0.1 M KCl) for labetalol. The potentiometric method was found to be accurate and easily applicable. The operational criteria for applying the methodology are indicated.
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