Abstract

PurposeThe purpose of this study is to investigate the differences between obtained percentage dose enhancements in areas around nanoparticles in GNPs (gold nanoparticles) enriched medium and percentage dose enhancements in the entire GNPs enriched medium including nanoparticles region. Methods and materialsTo verify the accuracy of Ir-192 source simulation, the obtained values of air kerma strength, dose rate constants, and radial dose functions were compared against previously published results. Then a 1 cm × 1 cm× 1 cm tumor volume loaded with different diameters of GNPs were considered at a source to the tumor center of 1 cm. Finally, dose enhancements were obtained for 50, 100 and 200 nm GNPs as a function of various concentrations of the radiosensitizer and depth in phantom. ResultsCalculations showed that dose enhancement could be customized by varying the size of nanoparticles, concentrations and radial distance from the source. The highest PDEGNP (The ratio of the increased deposited dose in the tumor region to the dose deposition in the no nano gold-containing structure) was acquired by 50 nm nanoparticles, 30 mg/g concentrations and in the highest distance from the source. (PDEGNP) and (PDEaround−GNP) due to the presence of 7–30 mg/g concentration of GNPs ranged from 3−18.19% and 3.45–21.13%, respectively. The results of this study revealed that the correlation is significant at the 0.01 level and there is a non-negligible difference (up to 3%) between (Daround−GNP)and (DGNP). ConclusionBy considering exclusively determination of dose enhancement in the just tumor tissue, calculating (Daround−GNP) Instead of DGNP may be a strategy for clinical use of nanoparticles in the radiation therapy. The results showed that with the increasing trend of dose enhancement in the GNPs loaded-tumor, dose enhancement decreases with an increase in the size of GNPs.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.