Abstract
One of the negative consequences of the increased use of medicines is the potential reason for releasing various pharmaceutical residues into the environment. Continuous development of analytical methodologies to identify and quantify such chemicals in natural waters is important to public health. This study aimed to set up a sufficiently sensitive LC-MS method to quantitate targeted androgens and estrogens in water samples. Method development was based on the official EPA Method 539:2010. In our experiments, estrogens were analyzed in the form of their dansyl derivatives. Such derivatization, using parallel (multiple) reaction monitoring (PRM) mode, improved sensitivity of the original method for estrogens by one or two orders of magnitude. Using electrospray in positive ionization (HESI+) mode resulted in a robust, selective, and sensitive method to quantify the targeted steroids with 10 pg L−1 method detection limit (MDL). The linearity of the method was good with correlation coefficients (R) in the range of 0.997–1.000 and with a calibration range of 5–1000 pg L−1 in drinking water. The method was successfully applied to analyze drinking water and mineral water samples collected in the area of Pécs (Baranya County, Hungary).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
