Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city

Abstract

Coronavirus infection a new infectious illness brought on by the SARS-COV-2 virus has infected people worldwide as of 2019, a covid-19 disease is associated with hematological and biochemical parameters changes. The present study aimed to evaluate the possible relationship between patient parameters and disease severity. A total of 200 nasopharyngeal swabs and whole blood specimens were collected from individuals suspected of CoV-2 and healthy volunteers as control of both sexes, grouped into four groups:50 patients for each mild, moderate, and severe patients and 50 healthy volunteers. The current study demonstrated that female 82(55%) was more frequently affected than male 68(45%). Hematological parameters including white blood cell count (WBC), granulocyte count, and Red blood cell distribution width (RDW%) (increased significantly p < 0.05, while Lymphocyte count decreased significantly when compared with a control group. Significant differences in hemoglobin concentration, packed cell volume, red blood cell count, and indices of red blood cell count were shown when compared with a control group in both sexes. Regarding biochemical parameters including serum vitamin D, ferritin, D-dimer, procalcitonin (PCT), and liver function tests, serum vitamin D decreased significantly, while serum ferritin, D-dimer, procalcitonin and liver enzymes increased significantly in the covid-19 patients group compared to the control group. According to vitamin D receptor ,gene polymorphism in covid-19 patients genotype Bb was most likely associated and strongly related to getting infected with CoV-2 virus with all the three known stages of infection.Severity of CoV-2 was associated with leukocytosis, lymphopenia and biomarkers are the best predictors of severe CoV-2, with a strong relation of VDR gene polymorphism BsmI with the severity of CoV-2 patients