Abstract
Simple methods to quantify radiochemical impurities existing in glass microspheres were tested. A system of two solvent mobile phases (acetone and 0.9% NaCl) were used with Whatman no. 3 paper strips as the stationary phase. Paper chromatography was used to identify radiochemical impurities in the radioactive microspheres. These impurities were found to be <0.01% for Azer spheres in saline and acetone solution. The results confirmed that glass microspheres prepared using the new procedures are convenient for radiotherapy purposes.
Highlights
Chromatography is the collective term for a set of laboratory techniques for the separation of mixtures into their components
This study developed a type of paper chromatography to determine the radiochemical purity of radioactive microspheres
The present study developed a type of paper chromatography for determination and comparison of the radiochemical purity of radioactive yttrium-90 microspheres produced by sol gel method and different composition 1) TEOS: H2O: HCl (Azer spheres) [14,15], 2) TEOS: CH3COOH:H2O (Azar spheres) [16], 3) TEOS: H2O: H3PO4, (Az spheres) [17]
Summary
Chromatography is the collective term for a set of laboratory techniques for the separation of mixtures into their components. All forms of chromatography work on the same principle. They all have a stationary phase (a solid or a liquid supported on a solid) and a mobile phase (a liquid or a gas). The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The mobile phase flows through the stationary phase and carries the components of the mixture with it. The various constituents of the mixture travel at different speeds, causing them to separate. There are different types of chromatography, including column chromatography and paper chromatography [1,2,3,4,5,6,7,8,9,10]
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