Abstract
The phytotochemical screening of Leaves, stem bark and root bark of Vitex doniana were carried out and some Lipid profile were assessed in normal albino rats after administration of the extracts. Twenty mixed sex Wistar rats weighing 150-200 g was divided into 4 groups. Group 1 serves as control while 2, 3, 4 were administered (100 mg/kg) aqueous extracts of leaves, stem bark and root bark of <em>Vitex doniana</em>. The phytochemical screening of the leaves, stem bark and root bark of <em>Vitex doniana</em> shows the presence of Glycosides, Cardiac glycosides, Saponins, Flavonoids and Tannins while the quantitative analysis showed a higher value in the amount of saponin present in the extracts. Daily oral administration of the extracts (100 mg/kg) for the period of 21days shows that all the extracts significantly (p<0.05) decreased the levels of serum total Cholesterol and LDL-cholesterol. The atherogenic risk predictor indices also showed that root bark extract significantly (p<0.05) increased HDL-Cholesterol/total cholesterol ratio which may possess antiatherogenic effect and therefore these findings may be of clinical importance to individuals at risk of cardiovascular disease.
Highlights
A medicinal plant is any plant used for the extraction of pure substances either for direct medicinal use or for hemi-synthesis of medicinal compounds which can be used for the therapeutic purpose or as a precursor for the synthesis of useful drugs (Sofwora, 1982)
The results of phytochemical screening of leaves stem bark and root bark extracts of Vitex doniana shows the presence of glycosides, cardiac glycosides, Flavonoids, saponin and tannin while the test for alkaloids, anthraquinone and Steroid and Tritepenes showed negative results (Table 1)
The quantitative analysis shows that Flavonoids had the highest value in leaves whereas tannin had the highest value in stem bark, there was no significant (p>0.05) difference between saponin and cardiac glycoside of leaves, stem bark and root bark of Vitex doniana (Table 2)
Summary
A medicinal plant is any plant used for the extraction of pure substances either for direct medicinal use or for hemi-synthesis of medicinal compounds which can be used for the therapeutic purpose or as a precursor for the synthesis of useful drugs (Sofwora, 1982). Some important groups of these phytochemicals (secondary metabolites) are involved in many in-vitro studies and assessment of haematological parameters, antioxidant activities, anti-microbial effect and analgesic effect (Finar, 1986). This indigenous knowledge, passed down from generation to generation in various parts of the world, has significantly contributed to the development of different traditional systems of medicine. This exploration of biologically active natural products have played an important role in finding New Chemical Entities (NCEs) for example, approximately 28% of NCEs between 1981 and 2002 were natural products or natural product-derived (Newman et al, 2003). This study was carried out to determine phytochemical constituents of the aqueous extracts of the leaves, stem bark and root bark of Vitex doniana and its effects on lipid profile of albino rats
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
