Abstract
This study evaluated the phenolic composition of the extract and fractions from E. platysema leaves, in addition to antibacterial activity against different types of bacteria, like mollicutes and cel wall bacteria. The crude extract (CHE) was partitioned with solvents to yield fractions of different polarities (dichloromethane, ethyl acetate, butanol and water). The chemical composition of CHE and its fractions were evaluated by HPLC-LC-ESI-MS/MS together with 76 standard phenolic compounds. Nine known compounds were identified for the first time from this species: hydroxybenzoic-O-hexoside acid [1], gallocatechin [2], syringic acid [3], 4-hydroxycinammic acid [4], salycilic acid [5], isoquercetin [6], isorhamnetin [7], luteolin-3’-O-glucuronide [8] and luteolin [9]. The evaluation of antibacterial activity was performed using the broth dilution method. The CHE and fractions of E. platysema were active against mollicutes strains, being the best result presented by the dichloromethane fraction against U. urealyticum, M. mycoides subsp. Capri and M. hominis (125 µg mL-1).
Highlights
Microorganisms are one of the most frequent causes of diseases, representing as a serious public health problem for a large portion of the population
This study evaluated the phenolic composition of the extract and fractions from E. platysema leaves, in addition to antibacterial activity against different types of bacteria, like mollicutes and cel wall bacteria
The CHE and fractions of E. platysema were active against mollicutes strains, being the best result presented by the dichloromethane fraction against U. urealyticum, M. mycoides subsp
Summary
Microorganisms are one of the most frequent causes of diseases, representing as a serious public health problem for a large portion of the population. The mollicutes are organisms responsible for several diseases such as pneumonia and pyelonephritis, both in humans and in animals. Some strains like Mycoplasma hominis and Ureaplasma urealyticum are a common commensal of the female genital tract and have been associated with pyelonephritis, bacterial vaginosis, cervicitis, endometritis, and postpartum septicemia. U. urealyticum is considered as the main cause of nonchlamydial, non-gonococcal urethritis, chorioamnionitis, preterm delivery, abortion, preterm birth, bacterial vaginosis and cervicitis (Amirmozafari et al, 2009; Falk et al, 2005; Naessens et al, 1989; Taylor et al, 2013). There is an importance in researching new active compounds against these microorganisms from various sources, including natural products (Benfatti et al, 2010)
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