Abstract
A correlation between absorbance value in the near infrared (NIR) range and granule particle size may allow measurement of particle growth during granulation. The effect of various grades of microcrystalline cellulose on NIR reflectance spectroscopic measurement was studied. Three grades with different median particle sizes and a mixture of these were fluidized in a bench-scale granulator. The absorbance was measured with a special NIR set-up during the fluidization of dry materials. It proved possible to differentiate the various grades of microcrystalline cellulose. The results show that the method described is a promising tool for on-line determination of particle size.
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