Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients

Abstract

Determination of Paraoxonase 1 Activity and Phenotype Distribution in Cervical Disk Herniation Patients
 
 Abstract
 Objectives: Cervical disk herniation (CDH) is a common disease that usually develops as a result of intervertebral disk degeneration (IVDD) or trauma, which can cause pain or neurological deficiency by nevre root or spinal cord compression. Paraoxonase 1 (PON1) has antioxidant qualities, and its function may vary based on genetic variations and ethnic background. This study aims to compare PON1 activity and phenotype distribution in CDH patients and individuals without the condition.
 Materials and Methods: This study involved 70 CDH patients and 70 individuals in good health. Spectrophotometric tests were conducted to measure the serum PON1 and arylesterase (ARE) activities. The PON1 ratio, which indicates the salt-stimulated PON/ARE level, showed a three-peak distribution. This ratio was utilized to determine the various phenotypes; QQ, QR, and RR for each participant.
 Results: The PON1 activity was lower in CDH patients compared to the healthy individuals (p < 0.05). CDH patients exhibited a statistically significant QQ phenotype in comparison to the healthy participants (p < 0.05).
 Conclusion: Patients with CDH exhibited significantly reduced PON1 activity, indicating that low PON1 activity and the PON1 QQ phenotype could potentially be a risk factor for the development of CDH.
 Keywords: Cervical disk herniation, Paraoxonase, Phenotype, PON1