Effects of smoking on serum paraoxonase 1 activity and carotid atherosclerosis

Abstract

Objective To explore the effects of smoking on serum paraoxonase1( PON1) activity and carotid atherosclerosis. Methods 478 subjects from residents of health screening for cardiovascular disease were enrolled from June 2012 to July 2014 in Huangpu district, shanghai. Smoking, drinking, exercise and cardiovascular disease risk factor data were recorded and gathered. All subjects accepted carotid artery ultrasound examination and were measured serum PON1 activity. The lowest quartile of serum PON1 activity level was taken as low PON1 activity level. Results (1) Serum PON1 activity in smokers was lower than that in non-smokers((206.5±25.6)kU/L vs (230.9±38.1)kU/L, P<0.01), incidence of carotid artery atherosclerosis in smoking group was higher than non-smoking group(75.7% vs 56.1%, P<0.01). (2) Multivariate logistic regression analyses indicated smoking, lack of exercise, creatinine, LDL-C were the independence factors of PON1 activity. (3) Multivariate logistic regression analyses indicated smoking, serum PON1 activity, age, gender, systolic pressure, were the independence factors of carotid atherosclerosis. Conclusion Smoking reduces serum activity. Smoking and lower serum PON1 activity level are independent risk factors of carotid atherosclerosis. Key words: Smoking; Paraoxonase 1; Carotid atherosclerosis; Risk factors