Determination of pantoprazole in pharmaceutical preparations by linear sweep, square wave and differential pulse voltammetric methods

Abstract

In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of pantoprazole in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of pantoprazole at platinum electrode in acetonitrile solution containing 0.1 M LiCIO4. The well-defined oxidation peak was observed at 1.17 V. The calibration curves were linear for pantoprazole at the concentration range of 5-50 µg/mL for LSV, SWV and DPV methods, respectively. Intra- and inter-day precision values for pantoprazole were less than 4.78, and accuracy (relative error) was better than 2.00%. The mean recovery of pantoprazole was 99.9% for pharmaceutical preparations. No interference was found from three tablet excipients at the selected assay conditions. Developed methods in this study are accurate, precise and can be easily applied to Protonex, Pandev and Panref tablets as pharmaceutical preparation.