Abstract
The aim of this study was to develop and validate an HPLC method for the determination of paclitaxel in plasma from cancer patients in the presence of paclitaxel metabolites and premedication drugs. The HPLC system involved a symmetry C18 column with a mobile phase of methanol, ammonium acetate buffer and isopropanol and UV detection at 230 nm. Paclitaxel and docetaxel were well separated and resolved within a run time of 25 min. Cyanopropyl solid-phase extraction (SPE) cartridges were used in the extraction procedure. The proposed method was successfully used to determine the concentration of paclitaxel in plasma from a cancer patient.
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