Abstract
Mevalonic acid in urine is converted to its lactone form by incubation overnight at acidic pH, extracted and analysed by GC–MS. The lower limit of quantitation of 7.5 ng/ml provides adequate sensitivity to measure changes in urinary excretion of MVA following administration of drugs which affect cholesterol synthesis. The assay is linear up to 300 ng/ml and has acceptable precision (<15%) and accuracy (<±20%) across the calibration range.
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