Abstract
A reversed-phase high-performance liquid chromatographic assay method was developed and validated for the simultaneous determination of methylparaben and propylparaben preservatives and chlorpromazine hydrochloride active component in a liquid oral pharmaceutical formulation. The method separated the analytes as well as some degradants and other components, providing good resolution and moderate tailing. The performance of various C 18 columns was compared. There were significant differences in selectivity and only a few phases showed acceptable tailing without the addition of triethylamine modifier in the mobile phase.
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