Determination of Methdilazine by Extractive Colorimetric Method from Pharmaceutical Dosage Form

Abstract

Simple sensitive and accurate ion pair complex formation, extractive spectrophotometric methods have developed for the estimation of methdilazine hydrochloride in pharmaceutical dosage form. The methods are based on the formation of ion paired coloured complexes by the drug with reactive dyes like Congo red, picric acid and methyl orange in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 490 nm, 400 nm, and 430 nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition method. The linearity was found to be 1-10 μg/ml, 2-12 μg/ml, and 1-14 μg/ml for methods respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of methdilazine hydrochloride in pharmaceutical dosages.