Abstract
The objective of this study was to determine the intrinsic drug dissolution rate (IDR) and the solute effective transport rate of some drugs, using a single particle dissolution technique, satisfying qualified dissolution conditions. The IDR of three poorly water-soluble compounds was measured in milli-Q water using four different fluid velocities. The enveloped surface area of the particles was calculated from the projected area and the perimeter of the particle observed in the microscope. Furthermore, computational fluid dynamics (CFD) simulations were used to theoretically investigate the flow conditions and dissolution rate, comparing box shaped particles and spherical particles with similar dimensions and surface area as the particles used the experiments. In this study, the IDR measurement of the single particles was determined within 5–60 min using particles with an initial projected area diameter () between 37.5–104.6 µm. The micropipette-assisted microscopy technique showed a good reproducibility between individual measurements, and the CFD simulations indicated a laminar flow around the particles at all flow velocities, even though there were evident differences in local particle dissolution rates. In conclusion, the IDR and solute effective transport rate were determined under well-defined fluid flow conditions. This type of approach can be used as a complementary approach to traditional dissolution studies to gain in-depth insights into the dissolution process of drug particles.
Highlights
Dissolution studies are frequently performed during the development of pharmaceutical products
The intrinsic dissolution rate (IDR) of single particles as well as the Computational fluid dynamics (CFD) simulations, it was that laminar fluidfluid flowflow occurred around the solute effective transport rate wereconcluded determined under laminar at a series of fluid particles during the dissolution process
The size of the particles used had a D p of 37.5–104.6 μm and the dissolution was gated for both shaped and spherical particles and it was for found that of differmonitored by box a micropipette-assisted microscopy technique periods
Summary
Dissolution studies are frequently performed during the development of pharmaceutical products. Dissolution methods can be divided into two categories, namely, methods to study the dissolution of single substances and methods to study the dissolution of formulated products. The former methods are typically used during preformulation and the latter methods during formulation development and quality control, e.g., as a means to predict the in vivo product performance [1,2]. The most frequently used indicator seems to be a surface area normalized dissolution rate (SAND), denoted
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
