Abstract
In this study, the in vitro antifungal activity of (3-(4-chlorophenyl)-4,5-dihydroisoxazole-4,5-diyl) dimethanol compound (1) was investigated against two pathogenic fungi species (Trichophyton mentagrophytes and Microsporum canis) and important results were obtained. The difficulty of treating fungal diseases induced us to assess the antifungal properties of dihydroisoxazole dimethanol compound. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC). The compound (1) showed an antifungal effect with MIC=12.5 µg ml-1 on M. canis and MIC=50 µg ml-1 on T. mentagrophytes, respectively. To prepare potentially more effective antifungal agents, new dihydroisoxazole derivatives (2-32) were theoretically designed. The geometrical optimization of all compounds (1-32) was performed using the semi-empirical AM-1 level. Some structural parameters of the optimized compounds (1-32) were also calculated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
