Abstract
Instrumental methods of analysis are frequently used to determine the level of a compound, class of compounds, or other chemical property on the studied item. The ability to adequately quantify measurement result uncertainty is crucial for the objective that triggered the chemical analysis. A tutorial and spreadsheet for the validation and bottom-up uncertainty evaluation of quantifications performed by instrumental methods of analysis based on linear weighted calibrations was presented by Ricardo J.N. Bettencourt da Silva of the University of Lisbon in Lisbon, Portugal, and his colleagues. This software tool was successfully applied to the determination of the mass concentration of cadmium, lead, arsenic, mercury, cobalt, vanadium, and nickel in a nasal spray by inductively coupled plasma–mass spectrometry (ICP-MS) after samples dilution and acidification. Bettencourt da Silva spoke to Spectroscopy about applying this software tool and the implications for a better understanding of quantitative analytical results.
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