Abstract
In the work, a method of application of scanning flow cytometry for investigation of the aggregation dynamics of invitro activated thrombocytes is presented. As a result, the rate constant of creation of initial aggregates, – dimers, – from single thrombocytes, and the effective steric factor of aggregation, which characterized the thrombocytes activation degree, are determined. The study reveals diagnostic potential of the scanning flow cytometer in determination of relative concentrations of aggregates and non-aggregated thrombocytes in a sample by measuring light-scattering signals from single particles and evolution of the distribution function of the particles on the signals. Theoretical treatment of the experimental data is based on modeling the particles aggregation kinetics with the use of Smoluchovski equation.
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