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Abstract
AbstractLong‐term exposures over 96 h provide valuable information on the behavior of toxic chemicals that cannot be obtained from short‐term tests. Time‐dependent LC50 and dose‐time‐response plots are important in evaluating the toxicity of chemical compounds to test organisms. However, their use is limited because of cumbersome calculations. To circumvent this, a BASIC program was developed that is based on the multivariate linear model theory. The main program, MULTILC, runs on an IBM PC and generates an equation that describes dose‐time‐response relationships. From this equation, time‐dependent LC50 values and their 95% confidence intervals are calculated. In addition, the subprogram, 3DGRAPH, draws a series of plots on the computer screen, including a three‐dimensional dose‐time‐response surface.
Published Version
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