Abstract
A simple, rapid and precise Electromagnetic Instrument Based Method (Conductometry and Potentiometry) has been developed for the determination of Dissociation constant. Dissociation constant is playing a great role in the drug absorption in vivo, especially in case of oral administration. So, in drug designing, pKa i.e. the negative logarithm of dissociation constant determination is very important. In this regards we report electromagnetic types of instrument-based procedures with principles elaborated to determine the Pka of Enalapril Maleate, an ACE inhibitor type of antihypertensive drug. The Dissociation Constant (PKa) of Enalapril Maleate was found to be 2.7 and 2.6 by the Potentiometric titration and Conductometry methods respectively.
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