Abstract
Clopidogrel (CPD) is prodrug converted endogenously to an unstable active metabolite and an inactive carboxylic acid metabolite. Therefore, CPD is the required analyte in bioequivalence and bioavailability studies. Development and validation of an LC-MS/MS determination of CPD was performed with the aim to be applied for pharmacokinetic analysis. CPD and ticlopidine (TPD, internal standard) were extracted from 200 µL of human plasma with ethylacetate. Chromatographic …
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