Abstract
Betamethasone sodium phosphate (BMNaP) has been employed as an electroactive material in the design of an ion-selective electrode (ISE). The electrode incorporates PVC membrane with betamethasone sodium phosphate-lidocaine ion pair complex. The influences of membrane composition, temperature, pH of the test solution, and the interfering ions on the electrode performance were investigated. The sensor exhibits a Nernstian response for betamethasone sodium phosphate ions over a relatively wide concentration range (1.0 × 10−1 to 1.0 × 10−5 M) with a slope of 28.4 ± 0.9 mV per decade at 25°C. It can be used in the pH range 4.0–10.0. The isothermal temperature coefficient of this electrode amounted to −0.0008 V/°C. The membrane sensor was successfully applied to the determination of betamethasone sodium phosphate in pharmaceutical products.
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