Abstract
The main objective of this study was to synthesize the molecularly imprinted boron nitride material and develop a high efficient method for extraction of the residue of veterinary drug in food sample. During the experiments, the molecularly imprinted microspheres with 2-aminobenzimidazole as the template were polymerize on boron nitride to synthesize a type of new composite. Then it was used as absorbent to develop a dispersive solid phase microextraction method for purification of benzimidazole drugs in beef followed by determination with ultra performance liquid chromatography. This composite could simultaneously recognize 7 benzimidazoles with high absorption capacity (36.23–38.88 μg/mg) and high recovery (92.3%-97.1%), and could be reused for 5 times. This sample extraction method achieved high enrichment factors (21.5–37.9), so the limits of detection for determination of the 7 drugs in beef were in the range of 0.2–0.5 ng/g. This is the first study reporting the use of boron nitride based material for the extraction of residual veterinary drug in food sample.
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