Abstract
In this study, it was aimed to determine the anti-bacterial activities of plant essential oils such as thyme, rosemary, sage, linden, black seed, bay leaf, peppermint, parsley, cinnamon and oleagen on vancomycin resistant enterococci (VRE) and pathogenic microorganisms of clinical importance. In the study, the inhibition zones of the plant extract of 10 plants prepared at 2.5 and 5 mg / mlconcentrations of VRE and various pathogenic microorganisms were detected by Disk Diffusion and Agar Well Diffusion Method. Following this, Minimal Inhibition Concentration (MIC) values of these extracts were determined. The activities of plant extracts on DNA and Gas Chromatography-Mass Spectrometry (GC-MS) analyzes were also performed. According to the data obtained, it was determined that the extracts of rosemary and sage plants showed high antibacterial effect against pathogenic bacteria. The rosemary extract was found to be the most effective extract on VRE strains, as well as medium-grade antibacterial effects on the VRE strains in oleaster, linden, thyme and mint extracts. It was also determined that extracts from different plants did not cause any change in the structure of DNA. In our study, it was determined that plant extracts that are especially effective on VRE strains have the potential to be used in the treatment of VRE. The results of this study should be taken into account in the research of drugs that can be used in the treatment of VRE and more in vitro and in vivo research should be carried out in this field.
Highlights
Enterococci are found as natural flora bacteria in the mouth, vagina, bile ducts and urethra on the surface of the human intestine (Çaylan, 2004)
Bacterial Cultures In order to determine the antimicrobial activity of plant extracts in our study, Enterococcus feacalis ATCC 29212, Staphylococcus aureus ATCC 29213, Enterobacter aerogenes ATCC 13048, Pseudomonas aeruginosa ATCC 27853, Bacillus subtilis ATCC 23857, Bacillus cereus ATCC 14579, Escherichia coli ATCC 25922, Aeromonas hydrophila ATCC 7966, Shigella dysenteriae ATCC 11835, Listeria monocytogenes ATCC 19111, Proteus mirabilis ATCC 29906 were obtained from the Microbiology Laboratory of the Faculty of Arts and Sciences at Kırşehir Ahi Evran University
Antimicrobial Activity of Plant Essential Oils It is about disc diffusion method, in which 10 different essential oils have different effects (2.5 mg/ml and 5 mg / ml) for pathogenic microorganisms
Summary
Enterococci are found as natural flora bacteria in the mouth, vagina, bile ducts and urethra on the surface of the human intestine (Çaylan, 2004). In addition to having a low rate of disease ability, they can cause serious diseases (Shepard and Gilmore, 2002). While these bacterial groups, which are found intensely in the abdominal cavity, cause infectious diseases such as bacteremia and endocarditis, they may rarely cause meningitis, skin and soft tissue infections. It is resistant to dry conditions; Enterococci can remain in hospital settings for a long time and spread among patients. It may predominate the gut microbiota of long-term hospitalized patients, especially those who taking broad-spectrum antibiotics (Reyes 2016)
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