Abstract
A gravimetric technique is proposed for the determination of antibodies to Yersinia enterocolitica serovar O: 3 using a piezoelectric quartz crystal immunosensor based on immobilized lipopolysaccharides. Conditions are optimized and a procedure is developed for the flow-injection analysis of blood serum samples using the immunosensor as the detector. The detection limit for antibodies is found to be 1.3 μg/mL, RSD is 8%, and the analytical range is 3–100 μg/mL. The rapidity (the duration of analysis was no longer than 10 min) and the direct detection of the formed agglutinate without additional labeling are the advantages of the proposed technique.
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