Determination of acute toxicity of the ‘Bondarmin’ disinfectant when administered intraperitoneally to laboratory animals

Abstract

The article presents the results of the study of the acute toxic effect of the innovative disinfectant ‘Bondarmin’ (active substance — potassium peroxomonosulfate) on laboratory animals (mice, rats) are presented. Many scientific works of scientists in recent years have been devoted to the study of the toxicity of various disinfectants both in our country and abroad. However, today there are many topical issues regarding the toxicity and safety of some antimicrobials. Our work aimed to study the toxic effect on the laboratory animals and to establish the acute toxicity (LD50) of the developed disinfectant ‘Bondarmin’ when administered intraperitoneally. Experiments were carried out in the Laboratory of Pharmacology and Toxicology of the National University of Pharmacy (Kharkiv) and in the Educational and Scientific Laboratory of Genetic and Molecular Research Methods named after P. I. Verbitskiy in the Kharkiv State Zooveterinary Academy. Acute toxicity assessment (LD50) was carried out with intraperitoneal administration of the designed disinfectant to laboratory animals (mice, rats). The toxic effect of the newly developed disinfectant ‘Bondarmin’ for the intraperitoneal method of administration to laboratory animals (mice, rats) has been determined. For the intraperitoneal administration of the ‘Bondarmin’ disinfectant, the LD50 by Prozorovskiy method is 316.85 ± 19.26 mg/kg for mice, and 279.33 ± 19.80 mg/kg for rats. The disinfectant belongs to the IV toxicity class (low toxic substances). The results of toxicological studies allow us to recommend the use of ‘Bondarmin’ for disinfecting livestock facilities