Abstract
A fast, simple and accurate method to determine the concentration of E-1100, a novel β-lactam antibiotic, in rat plasma has been developed. This method involves deproteinization by methanol with 0.2% perchloric acid and reversed-phase high-performance liquid chromatography with ultraviolet detection. Regression analysis showed that the method was linear over the standard-curve range from 0.191 to 191.0 μg/ml. This newly developed method has been applied for the analysis of plasma samples in a preliminary pharmacokinetic study in rats.
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