Abstract
The solid-liquid equilibrium data of eszopiclone in six pure organic solvents and two binary mixed systems was determined by employing a gravimetric method under atmospheric pressure at temperatures ranging from 288.15K to 328.15K. For each selected solvent, the solubility data of eszopiclone increases with increasing temperature. It was found that composition of mixed solvents has a significant influence on the solubility of eszopiclone, that there exhibits a synergistic effect at some certain composition points for both mixed systems. Experimental solubilities were fitted by different models including the modified Apelblat equation, λh model, CNIBS/R-K model and the Hybrid model, the calculated results were found to agree well with the experimental data. At last, the van't Hoff equation was employed to calculate the thermodynamic parameters of all selected solutions, corresponding results confirm that these dissolving processes are endothermic and entropy-driving.
Published Version
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