Determination and analysis of solubility of brassinolide in different solvent systems at different temperatures (T = 278.15–323.15 K)

Abstract

Brassinolide is a new environmental protection plant growth regulator. With the aim of knocking down selfcost and scale up agriculture market-place emulation, come what will manufacture method is adopted, the final step crystallization is significant for getting exclusive substances. The purpose of this study is to provide some authentic and general energetics data for the actual industrial production of brassinolide. In the research, the solid–liquid equilibrium of brassinolide in twelve pure solvents (tetrahydrofuran, dimethyl sulfoxide, ethanol, acetone, methanol, trichloromethane, acetonitrile, 1-butanol, isopropanol, xylenes, n-hexane and n-heptane) and three binary solvent mixtures (trichloromethane + tetrahydrofuran, acetonitrile + tetrahydrofuran and n-hexane + tetrahydrofuran) were tested by the circumstance of atmosphere pressure at range temperatures between 278.15 K and 323.15 K. Four models like the Buchowski–Ksiazaczak λh model, the modified Apelblat model, the Jouyban-Acree-van't-Hoff model and the Redich-Kister (CNIBS/R-K) model were employed to describe the change trend of solubility. On the groundwork of a series of data analysis, tetrahydrofuran is a better organic solvent and n-hexane can be applied as an effective anti-solvent when separating out brassinolides. These solubility data are very important for optimizing the extraction process and recrystallization of brassinolide.