Abstract
The success of rabies vaccination is characterized by the growth of seropositive antibody titers (?0.5 IU) after vaccination. One of the tests conducted to monitor antibody growth is ELISA (Enzyme Linked Immunosorbent Assay). This study aimed to determine the effect of different vaccine doses on the growth of rabies antibodies in kintamani dogs. The study was conducted using an experimental method with a study design using 2 variables, namely the difference in vaccine doses (0.5 and 0.75 cc) and the times of blood collection (1, 2 and 3 months after vaccination). Each vaccine dose was given to three kintamani dogs. Antibodies were measured using ELISA and data were analyzed with paired sample t-test between the treatment dose of 0.75 cc and 0.5 cc at months 1.2 and 3 after vaccination. The results showed that at first month the antibody titer were 2,12 IU at a dose of 0.75 cc and 3.72 IU at a dose of 0.5 cc. At second months, antibody titers were 7.74 IU (0.75 cc dose) and 10.85 IU (0.5 cc dose), while at third month, antibody titers were 5.73 IU (0.75 cc) and 9.00 IU (0.5 cc). Vaccine doses administered produce antibody titer levels that did not differ significantly between 0.75 cc and 0.5 cc doses.
 
 Keyword: Antibody, ELISA, Kintamani Dog, Rabies
Highlights
EISSN: 2655-8122 administered produce antibody titer levels that did not differ significantly between 0.75 cc and 0.5 cc doses
The results showed that at first month the antibody titer were 2,12 International Unit (IU) at a dose of 0.75 cc and 3.72 IU at a dose of 0.5 cc
Tingkat dan Faktor Risiko Kekebalan Protektif terhadap Rabies pada Anjing di Kota Makassar
Summary
INTISARI Keberhasilan vaksinasi rabies ditandai dengan tumbuhnya titer antibodi yang bersifat seropositif (≥0,5 IU) pasca vaksinasi. Salah satu uji yang dilakukan untuk memonitor pertumbuhan antibodi adalah ELISA (Enzyme Linked Immunosorbent Assay). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian dosis vaksin yang berbeda terhadap pertumbuhan antibodi rabies pada anjing kintamani. Penelitian dilakukan menggunakan metode eksperimental dengan rancangan penelitian menggunakan 2 variabel yaitu perbedaan volume vaksin (0,5 dan 0,75 cc) serta waktu pengambilan darah (1, 2 dan 3 bulan pasca vaksinasi). Antibodi diukur menggunakan ELISA dan data dianalisis dengan uji Paired sample t-test antara perlakuan dosis 0,75 cc dengan dosis 0,5 cc pada bulan 1, 2 dan 3 pasca vaksinasi. Pada bulan 2, titer antibodi adalah 7,74 IU/mL (dosis 0,75 cc) dan 10,85 IU/mL (dosis 0,5 cc). Dosis vaksin yang diberikan menghasilkan level titer antibodi yang tidak berbeda signifikan antara dosis 0,75 cc dan dosis 0,5 cc
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