Abstract
BackgroundProstate cancer is known to have ethnic and regional differences. The study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center.MethodsBetween October 2009 and September 2016, a total of 1027 Chinese men, who had undergone TRUS-guided prostate biopsy at Qingdao Municipal Hospital, were retrospectively analyzed. Prostate biopsies were performed in the case of an abnormally elevated serum PSA level, and/or abnormal digital rectal examination (DRE) findings, and/or suspicious prostatic imaging findings.ResultsOf the 1022 men enrolled in the analysis, 438 patients (42.8%) were diagnosed with prostate adenocarcinoma histologically. When serum PSA levels were divided into five subgroups (less than 4.0, 4.0 to 10.0, 10.0 to 20.0, 20.0 to 100.0, and ≥ 100.0 ng/ml), the detection rates of prostate cancer were 12.4, 15.9, 34.1, 66.2, and 93.8%, respectively. With serum PSA levels of 4.0 to 10.0 ng/ml, the cancer detection rates for a normal DRE and a suspect DRE finding were 13.5 and 58.2%, respectively. Accordingly, the cancer detection rates for a normal imaging and a suspect imaging finding were 13.5 and 58.2%, respectively. Besides, a large proportion of the patients were in the clinically advanced stage.ConclusionsThe present study data reported a relatively higher prostate cancer detection rate of 42.8% and that the majority of the patients presented with clinically advanced prostate cancers within a local clinical urologic practice. An early detection and screening program for prostate cancer is of great need to reduce the burden from this disease among the northern Han Chinese population.
Highlights
IntroductionThe study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center
Prostate cancer is known to have ethnic and regional differences
We retrospectively examined our clinical database of prostate biopsies from 2009 to 2016 and aimed to assess the detection rate of prostate cancer on biopsy in the northern Han Chinese population according to the serum prostate cancerProstate-specific antigen (PSA) level, digital rectal examination (DRE) finding, prostatic imaging finding, and subject’s age
Summary
The study aimed to clinically evaluate the detection rate of prostate cancer on transrectal ultrasonography (TRUS)-guided prostate biopsy and analyze its characteristics among the northern Han Chinese population at a single center. The incidence and mortality rates of prostate cancer. Emerging evidence has demonstrated that it has led to a dramatic increase in the incidence of prostate cancer around the world since the introduction of PSA in 1986 [9]. Digital rectal examination (DRE) and transrectal ultrasonography (TRUS) are another two common methods used to screen for signs of prostate cancer [10, 11]. As far as we know, there is no study available on the subject of the detection rate of prostate cancer and few data are available to describe the clinical and pathological characteristics of prostate cancers detected in the local area of Qingdao city, which is a famous costal city in Northern China
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