Abstract
Objective To investigate the differences in sex hormone levels between hypospadias and circumcision groups. Methods Fifty cases of circumcision and 137 cases of hypospadias the dihydrotestosterone (DHT) value was tested with radioimmunoassay, and testosterone was tested with lightimmunoassay. Results DHT value was (64.51±32.10)pg/ml in circumcision group, and (46.72±28.94)pg/ml in hypospadias group (P 0.05). No statistically significant differences were found in FSH among all types of hypospadias (P>0.05). Conclusions Inadequate secretion of T or activity insufficiency and functional deficiency of 5 alpha reductase (SRD5A) are likely found in children with hypospadia. Inadequate secretion and low T value might be found in LH-T shaft in children with hypospadia. The normal T value in some children with hypospadia does not show that androgens produced during pregnancy are normal. Key words: Hypospadias/ME; Gonadal steroid hormones/ME
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