The role of mullerian inhibiting substance in the development of hypospadias

Abstract

Objective To explore the role of mullerian inhibiting substance in the development of male hypospadias.Methods Fifty-four isolated hypospadias patients and 36 patients which suffered from other diseases were chosen as our research objects.Of the hypospadias patients,there were 11 patients were less than 12 months,24 patients from 13 to 24 months,and 19 patients from 25 to 36 months.Serum mullerian inhibiting substance,testosterone,and androstenedione were assayed,respectively.And the differences of the testosterone and mullerian inhibiting substance between these two groups were compared.Results The concentration of mullerian inhibiting substance in hypospadias group(122.0±21.7 ng/ml)was significantly higher than that in control group(80.5±11.4 ng/ml).While the concentrations of testosterone and androstenedione in hypospadias group were significantly Iower than those in control group.Furthermore.these two groups were divided into 3 subgroups according to their age.The concentrations of testosterone and androstenedione in hypospadias group whose age was less than 12 months and 13 to 24 months were significantly lower than those in control group.And the higher concentration of mullerian inhibiting substance was negatively related to the lower concentration of testosterone in hypospadias patients.and the relative coefficient was negative 0.31 and 0.42,respectively.Conclusions Mullerian inhibiting substance may inhibit the synthesization of testosterone.Mullerian inhibiting substance plays a part in the development of hypospadias. Key words: Hypospadias; Hormones