Abstract
Objective To investigate the relationship between serum levels of serum tumor necrosis factor-α(TNF-α)and low-density lipoprotein cholesterol(LDL-C)in patients with coronary heart disease and their significance. Methods All persons were divided into three groups: acute coronary syndrome(ACS)group, stable angina pectoris(SAP)group and control group. The serum levels of TNF-α were measured by enzyme-linked immunosorbent assay. Results The serum levels of TNF-α and LDL-C in ACS and SAP groups were significantly higher than that in the control group(P<0.05). The serum levels of TNF-α and LDL-C in the ACS group were significantly increased compared with those in the SAP group(P<0.05). The analysis of Pearson binary variables in coronary heart disease(ACS, SAP)groups implied serum levels of TNF-α and LDL-C had significant positive correlation. Conclusions TNF-α and LDL-C were both involved in the development of coronary heart disease. Their serum levels may be used as indicators for coronary heart disease risk stratification. Key words: Coronary heart disease; Tumor necrosis factor-α; Low-density lipoprotein cholesterol
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