Detection of Polycystic Ovary Syndrome and Its Treatment with Pergularia daemia in Rat Models

Abstract

Polycystic Ovary Syndrome (PCOS) is a heterogeneous, multifaceted disorder which affects mostly the women in the reproductive stage with unclear etiologies. This syndrome is associated with clinical, endocrinological and metabolic dysfunction. The ultimate aim of this research is to analyze about the estrous cycle in the PCOS induced rat models and its treatment with a common trellis vine called Pergularia daemia. Female albino wistar strain rats were given Testosterone Propionate an androgenic hormone intraperitoneally to induce PCOS. The PCOS affected rats were treated orally with the leaf extract of P. daemia. The vaginal smears were observed for a period of 15 days for three different groups namely control, PCOS induced and P.daemia treated. The result shows that irregularity of estrous cycle phase in the PCOS induced group. The remarkable changes were found in the P.daemia treated group by normalizing the estrous cycle and it is quite similar to the control. The statistical analysis also proves that there is a similarity (P < 0.05) between the control and the P.daemia treated group through One way ANOVA. Thus, the current study strongly proves that P.daemia is an effective drug in treating the PCOS which is a major reason for the cause of infertility.