Detection of plasma urokinase-type plasminogen activator and its receptor in acute or chronic hepatitis B patients and its clinical significance

Abstract

To study the expression of plasma uPA and uPAR in Acute or Chronic Hepatitis B patients, to investigate changes of blood fibrinolytic system in Hepatitis B and its clinical significance. The level of detected plasma urokinase-type plasminogen activator (uPA) and urokinase-type plasminogen activator receptor (uPAR) were measured by Enzyme Linked Immuno Sorbent Assay (ELISA). The levels of plasma uPA and uPAR were significantly higher in patients with Acute or Chronic Hepatitis B than that of control group (P less than 0.05, P less than 0.01), and also higher in serious group than that of non-serious group of Chronic Hepatitis B patients (P less than 0.05), and also higher in chronic group than in acute group (P less than 0.05). The level of plasma uPAR was significantly higher in patients with serious jaundice than that of non-serious jaundice group (P less than 0.01). The levels of uPA and uPAR are significantly higher in acute period than that in recover period of Acute Hepatitis B patients, but the levels in recover period is also higher than that in control group. The level of plasma uPAR have positive correlation with prothrombin (PT), international normalized ratio (INR) and total bilirubin (P less than 0.01). The level of plasma UPA nad UPAR were enhanced in Acute or Chronic Hepatitis B patients was related with the degree of inflammation, was also related with high expression of serious damage of liver cell. It may be one of important cause to imbalance between coagulation and fibrinolytic in hepatitis.