Detection of pathogenic bacteria and drug resistance analysis on children with pulmonary infection in ICU and respiratory ward

Abstract

Objective To investigate the distribution and drug resistance of bacteria infection in children with pneumonia between pediatric intensive care ward and respiratory ward , in order to guide clinical treatment. Methods From 2010 January to 2014 January, two-hundred and sixty cases of pneumonia in hospitalized pediatric intensive care ward were included in the severe group, 300 patients from respiratory ward into the common group, severe group were divided into the mechanical ventilation group(126 cases), non mechanical ventilation(134 cases), mechanical ventilation were divided into invasive ventilation group(94 cases), noninvasive ventilation group(32 cases). Conventional sputum specimens were detected, bacterial culture, identification and drug resistance of pathogenic bacteria ratio were done in each case, to compare the pathogenic bacteria and drug resistance rate of different groups. Results Both severe group and common group , gram negative bacteria were significantly higher than those of gram positive, But in the severe group, gram negative bacteria ratio was significantly higher than the common group(P<0.05), while the positive bacteria ratio was significantly lower than that of common group(P<0.05). Stenotrophomonas maltophilia, Acinetobacter and Pseudomonas aeruginosa ratio in severe group were significantly higher than that of common group(P<0.05), while the Haemophilus influenzae and Streptococcus pneumoniae in common group was significantly higher than the proportion of severe group(P<0.05). Stenotrophomonas maltophilia, Acinetobacter, Pseudomonas aeruginosa ratio in ventilation group was significantly higher than that of non ventilation group(P<0.05), and in the invasive ventilation group was significantly higher than the proportion of noninvasive ventilation group(P<0.05). Multi drug resistant bacteria detection rate in severe group was significantly higher than the common group(P<0.05). Conclusion Both pediatric intensive care ward and respiratory ward , bacterial lung infections are dominated by Gram negative bacteria, but bacteria spectrum and drug resistance have obvious difference, multi drug resistant bacteria detection rate in pediatric intensive care ward significantly higher than that of respiratory ward.Mechanical ventilation especially invasive mechanical ventilation may easily lead to drug-resistant strains. Key words: Pediatric intensive care ward; Respiratory ward; Bacteria; Drug resistance