Abstract
Objective:To analyze the significance of myocardial enzymes, cardiac troponin T (cTnT) and hepatic and renal function in the treatment of severe pneumonia in children.Methods:One hundred and twenty children with severe pneumonia who were admitted to the hospital between April 2015 and February 2017 were selected and included as a severe pneumonia group; 120 children with common pneumonia were included as a common pneumonia group; 100 healthy children were included as controls. The myocardial enzymes, cTnT and hepatic and renal function of patients in the three groups were detected and compared. The children with severe pneumonia were divided into a mild hypoxia group, a moderate hypoxia group and a severe hypoxia group according to arterial partial pressure of oxygen; the myocardial enzymes, hepatic and renal function and cTnT of the children in the three groups were compared. The correlations of partial pressure of blood oxygen with myocardial enzymes, hepatic and renal function and cTnT were analyzed.Results:The levels of myocardial enzymes, hepatic and renal function and cTnT of the severe pneumonia group, common pneumonia group and control group declined, and the differences had statistical significance (P<0.05). The levels of myocardial enzymes, hepatic and renal function and cTnT were higher in the children with severe hypoxia. The partial pressure of blood oxygen was in a negative correlation with myocardial enzymes, hepatic and renal function and cTnT in the severe pneumonia group.Conclusion:Timely monitoring of myocardial enzymes, hepatic and renal function and cTnT has an extremely important role in the evaluation of children with severe pneumonia.
Highlights
Children have higher risks of severe pneumonia after being invaded by pathogenic bacteria because of the incomplete development of functional organs and immune system, insufficient respiratory mucosa secretory immunoglobulin A, weak cough and expectoration abilities and poor swallowing reflex
The severe pneumonia group included 70 males and 50 females; they aged from 6 months and 10 years; body mass was between 8.6 kg and 30.4 kg
The common pneumonia included 60 males and 40 females; they aged from five months and 10 years; the body mass of them was between 8.4 kg and 30.7 kg
Summary
Children have higher risks of severe pneumonia after being invaded by pathogenic bacteria because of the incomplete development of functional organs and immune system, insufficient respiratory mucosa secretory immunoglobulin A, weak cough and expectoration abilities and poor swallowing reflex Up to this day, severe pneumonia remains to be a common disease in the pediatric field and one of the factors inducing death.[1,2] An investigation suggested that about 14 million children under five years develop severe pneumonia every year around the world.[3] Besides hypoxia, severe pneumonia, Pak J Med Sci September - October 2018 Vol 34 No 5 www.pjms.com.pk 1257 an infectious disease with high death rate, can induce severe complications such as cardiac failure, disseminated intravascular coagulation and severe sepsis and lead to death.[4,5] Currently many indicators have certain references in reflecting the severity of severe pneumonia. It has been found that monitoring the dynamics of myocardial enzymes and cardiac troponin T (cTnT) has high values in evaluating the severity of severe pneumonia in children.[9,10] In this study, the values of detection of myocardial enzymes, cTnT and hepatic and renal function in the treatment of severe pneumonia in children were analyzed
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