Abstract
Retinal laser photocoagulation is used to treat several ophthalmic diseases. However, it is associated with damage to surrounding healthy tissue. Local tissue alteration during coagulation laser illumination was measured using phase-resolved optical coherence tomography (OCT) M-mode scan as a change in the local optical path length (LOPL). A metric that represents global net tissue alteration was defined using the LOPL change. The visibility of a laser lesion was assessed by three-dimensional OCT volume measurement. Multiple logistic regression analysis was performed to investigate the association between the introduced metric and the laser lesion visibility. The metric was found to be a statistically significant predictor of the laser lesion visibility independent to laser condition. The proposed method based on an LOPL change is thus promising for retinal photocoagulation monitoring.
Highlights
Retinal laser photocoagulation is used to treat several ophthalmic diseases, such as extrafoveal choroidal neovascularization, central serous chorioretinopathy, and diabetic retinopathy [1,2,3]
We present the detection of tissue denaturation during laser photocoagulation by an M-mode optical coherence tomography (OCT)-based measurement of the local tissue alterations in the axial strain and/or refractive index; i.e., local optical path length (LOPL) change [14]
The LOPL change rate gradually increased at the retinal pigment epithelium (RPE) depth (II)
Summary
Retinal laser photocoagulation is used to treat several ophthalmic diseases, such as extrafoveal choroidal neovascularization, central serous chorioretinopathy, and diabetic retinopathy [1,2,3]. The monitoring and/or prediction of the treatment is important in terms of avoiding unnecessary tissue malfunction. The monitoring of tissue denaturation has been demonstrated by detecting a change in the reflectance of tissue [4,5,6]. These methods are based on changes in optical properties due to tissue alteration [4]. The optoacoustic method monitors a change in the temperature of tissue [7]. Optical coherence tomography (OCT) has been used to detect a change in internal tissue due to photocoagulation [8,9,10,11]. Localized tissue monitoring will be suitable for the high-sensitivity detection of tissue damage
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