Conbercept and Retinal Photocoagulation in the treatment of Diabetic Macular Edema.

Weizhe Meng,Xiufen Xie,Ronghua Li

doi:10.12669/pjms.35.6.512

Abstract

Objective:To explore the clinical efficacy of intravitreal injection of conbercept in combination with retinal laser photocoagulation in the treatment of diabetic macular edema.Methods:Ninety patients with diabetic macular edema were selected and grouped into an observation group and a control group using random number table, 45 patients (45 eyes) each group. The control group was given retinal laser photocoagulation, while the observation group was given intravitreal injection of Conbercept on the basis of panretinal photocoagulation. The Best Corrected Visual Acuity (BCVA), thickness of retinal nerve fibre layer (RNFL) and macular thickness were measured through relevant examinations before and after treatment. The intraocular pressures of patients in the two groups were evaluated, and moreover the complications were recorded.Results:The RNFL thickness and macular thickness of the two groups had no statistically significant differences before treatment (P>0.05) and decreased significantly after treatment; the decrease amplitude of the observation group was significantly larger than that of the control group (P<0.05). The BCVA of both groups significantly increased in the 1st, 2nd and 4th week after treatment (P<0.05); the increase amplitude of BCVA of the observation group was more significant than that of the control group at different time points after treatment (P<0.05). The intraocular pressure of the observation group was not significantly different with that of the control group in the 1st, 2nd and 4th week after treatment (P>0.05). There were no severe eye complications and systemic adverse reactions in both groups in the process of follow up.Conclusion:Intravitreal injection of conbercept in combination with retinal laser photocoagulation performs better in improving the BCVA and central macular thickness of patients with diabetic macular edema compared to retinal laser photocoagulation and has high safety.

Highlights

With the improvement of people’s living standard, the incidence of diabetes has increased, and the number of diabetic patients has reached 420 million,[1,2] A study found that the incidence of diabetic retinopathy (DR) in type 2 diabetes mellitus was about 35%
Patients who had history of type 2 diabetes mellitus, had normal blood glucose level and pressure, were diagnosed by fluorescence fundus angiography (FFA), conformed to the diagnostic criteria for DR recommended by American Diabetes Association (ADA),[13] were diagnosed as macular oedema with clinical significance according to the standards of Early Treatment Diabetic Retinopathy Study, aged 40~80 years, had Best Corrected Visual Acuity (BCVA) between 0.01 and 0.6 before treatment, had no history of retinal vein obstruction and glaucoma, and had Diabetic macular edema (DME) in one eye were included
There was no significant difference in the retinal nerve fibre layer (RNFL) thickness and macular thickness between the two groups before treatment (P>0.05); but the RNFL thickness and macular thickness significantly decreased after treatment

Summary

Introduction

With the improvement of people’s living standard, the incidence of diabetes has increased, and the number of diabetic patients has reached 420 million,[1,2] A study found that the incidence of diabetic retinopathy (DR) in type 2 diabetes mellitus was about 35%.3 Diabetic macular edema (DME) is a common complication of DR and the primary cause of visual loss.[4]. With the improvement of people’s living standard, the incidence of diabetes has increased, and the number of diabetic patients has reached 420 million,[1,2] A study found that the incidence of diabetic retinopathy (DR) in type 2 diabetes mellitus was about 35%.3. Diabetic macular edema (DME) is a common complication of DR and the primary cause of visual loss.[4] The incidence of diabetic macular edema in DR patients was 7%.5. Laser photocoagulation is currently the main method for the treatment of diabetic macular edema.[6] It can improve visual acuity and delay the decline of visual acuity.

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Discussion

Conclusion