Detection of increased coronary microvascular permeability with MRI T1 mapping and gadolinium-labeled albumin

Sophia X Cui,Frederick H Epstein,Brent A French

doi:10.1186/1532-429x-18-s1-w3

Sophia X Cui, Frederick H Epstein + Show 1 more

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https://doi.org/10.1186/1532-429x-18-s1-w3

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Abstract

Background Conditions such as obesity and diabetes lead to coronary microvascular disease and, subsequently, an increased risk of adverse cardiac events. Increased microvascular permeability is thought to be an early biomarker of coronary microvascular disease. While prior studies have used MRI with gadolinium-labeled albumin, a macromolecular contrast agent, to detect myocardial infarction, we hypothesized that MRI T1 mapping with gadolinium-labeled albumin could detect more subtle changes in coronary microvascular permeability such as those induced by noninjurious pharmacological methods.

Highlights

From 19th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 27-30 January 2016. Conditions such as obesity and diabetes lead to coronary microvascular disease and, subsequently, an increased risk of adverse cardiac events
While prior studies have used MRI with gadolinium-labeled albumin, a macromolecular contrast agent, to detect myocardial infarction, we hypothesized that MRI T1 mapping with gadolinium-labeled albumin could detect more subtle changes in coronary microvascular permeability such as those induced by noninjurious pharmacological methods
T1 mapping was performed at baseline and at 7, 14, 21, and 28 minutes after administering gadolinium-labeled albumin (4 mL/kg; Galbumin, BioPal, Worcester, MA) and, in a separate session, at the same times without administering contrast agent

Summary

Introduction

Conditions such as obesity and diabetes lead to coronary microvascular disease and, subsequently, an increased risk of adverse cardiac events. Increased microvascular permeability is thought to be an early biomarker of coronary microvascular disease. While prior studies have used MRI with gadolinium-labeled albumin, a macromolecular contrast agent, to detect myocardial infarction, we hypothesized that MRI T1 mapping with gadolinium-labeled albumin could detect more subtle changes in coronary microvascular permeability such as those induced by noninjurious pharmacological methods

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