Abstract
In this study, we used localized surface plasmon resonances (LSPR) to observe a phenomenon of binding of DNA on Au and Au/Ag nanostructure arrays. Au and Au/Ag nanostructures of various geometric sizes and metal compositions were fabricated by colloidal lithography technique. The immobilization of capture DNA and subsequent hybridization with target DNA on the nanostructures caused the shift of maximum peak in LSPR spectra of the nanostructures. Using the peak shift, the immobilization of capture DNA was clearly verified in a nondestructive manner and hybridization with complementary target DNA was reliably differentiated from the non-specific binding with noncomplementary DNA. This work firmly implies that the LSPR spectra of the nanostructrues can be efficiently utilized to achieve a novel strategy for the detection of DNA on the nanostructures.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
