Abstract
SummaryThe presence of antiglomerular basement membrane (GBM) and antitubular basement membrane (TBM) antibodies was tested by passive hemagglutination in the serum of 243 patients with renal diseases and 40 controls.Seven percent of nephritic patients had circulating antibodies for both GBM and TBM (titers 1/16 to 1/64). Negative results were always found in controls. Positive patients can be separated in three groups : focal glomerulonephritis (6 cases), diffuse glomerulonephritis with endo and extracapillary proliferation (5 cases), nephropathies with major vascular lesions (6 cases). Linear deposits of Ig G and βI C globulins were found in one patient with focal glomerulonephritis and in one patient with diffuse glomerulonephritis. In these two cases only, hemagglutinating anti-GBM antibodies exhibited a high affinity for basement membranes.
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